JPH0798819B2 - 置換架橋ジアザビシクロアルキルキノロンカルボン酸 - Google Patents

置換架橋ジアザビシクロアルキルキノロンカルボン酸

Info

Publication number
JPH0798819B2
JPH0798819B2 JP61220819A JP22081986A JPH0798819B2 JP H0798819 B2 JPH0798819 B2 JP H0798819B2 JP 61220819 A JP61220819 A JP 61220819A JP 22081986 A JP22081986 A JP 22081986A JP H0798819 B2 JPH0798819 B2 JP H0798819B2
Authority
JP
Japan
Prior art keywords
diazabicyclo
acid
oxo
dihydro
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP61220819A
Other languages
English (en)
Japanese (ja)
Other versions
JPS62103083A (ja
Inventor
マーティン・レイモンド・ジェフソン
ポール・ロバート・マックギーク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPS62103083A publication Critical patent/JPS62103083A/ja
Publication of JPH0798819B2 publication Critical patent/JPH0798819B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Photolithography (AREA)
JP61220819A 1985-09-18 1986-09-18 置換架橋ジアザビシクロアルキルキノロンカルボン酸 Expired - Lifetime JPH0798819B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77747185A 1985-09-18 1985-09-18
US777471 2001-02-06

Publications (2)

Publication Number Publication Date
JPS62103083A JPS62103083A (ja) 1987-05-13
JPH0798819B2 true JPH0798819B2 (ja) 1995-10-25

Family

ID=25110350

Family Applications (1)

Application Number Title Priority Date Filing Date
JP61220819A Expired - Lifetime JPH0798819B2 (ja) 1985-09-18 1986-09-18 置換架橋ジアザビシクロアルキルキノロンカルボン酸

Country Status (42)

Country Link
US (3) US4775668A (en])
EP (1) EP0215650B1 (en])
JP (1) JPH0798819B2 (en])
KR (1) KR870000961B1 (en])
CN (1) CN1014789B (en])
AT (1) ATE72245T1 (en])
AU (1) AU576302B2 (en])
BG (2) BG49275A3 (en])
CA (1) CA1340734C (en])
CY (1) CY1774A (en])
CZ (1) CZ277825B6 (en])
DD (1) DD259190A5 (en])
DE (2) DE19675019I2 (en])
DK (1) DK171276B1 (en])
EG (1) EG18184A (en])
ES (1) ES2001428A6 (en])
FI (1) FI87565C (en])
GR (1) GR862363B (en])
HK (1) HK132795A (en])
HU (1) HU200462B (en])
IE (1) IE58966B1 (en])
IL (1) IL80033A (en])
IN (1) IN166416B (en])
LU (1) LU90356I2 (en])
MA (1) MA20770A1 (en])
MW (1) MW5886A1 (en])
MX (1) MX173358B (en])
MY (1) MY102518A (en])
NO (1) NO170335C (en])
NZ (1) NZ217614A (en])
OA (1) OA08410A (en])
PH (2) PH24048A (en])
PL (1) PL149987B1 (en])
PT (1) PT83388B (en])
SG (1) SG28094G (en])
SK (1) SK667886A3 (en])
SU (1) SU1482531A3 (en])
UA (1) UA6340A1 (en])
YU (1) YU45024B (en])
ZA (1) ZA867063B (en])
ZM (1) ZM8586A1 (en])
ZW (1) ZW19386A1 (en])

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DE3601567A1 (de) * 1986-01-21 1987-07-23 Bayer Ag 7-(azabicycloalkyl)-chinoloncarbonsaeure- und -naphthyridon-carbonsaeure-derivate
EP0251308B1 (de) * 1986-07-04 1990-11-22 Chemie Linz Gesellschaft m.b.H. 4-Chinolon-3-carbonsäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4965273A (en) * 1986-10-08 1990-10-23 Bristol-Myers Company Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents
WO1989000158A1 (en) * 1987-07-02 1989-01-12 Pfizer Inc. Bridged-diazabicycloalkyl quinolone carboxylic acids and esters
US4968799A (en) * 1987-07-31 1990-11-06 Warner-Lambert Company Antibacterial agents
US4992546A (en) * 1987-07-31 1991-02-12 Warner-Lambert Company Process for preparing 6,8-diazabicyclo[3.2.2]nonane derivatives
US4923879A (en) * 1987-07-31 1990-05-08 Warner-Lambert Company 1,8-Naphthyridines and their use as antibacterial agents
US4933335A (en) * 1987-08-07 1990-06-12 Warner-Lambert Company Quinolones as antibacterial agents
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
DE3902079A1 (de) * 1988-04-15 1989-10-26 Bayer Ag I.m. injektionsformen von gyrase-inhibitoren
WO1990002123A1 (en) * 1988-08-23 1990-03-08 Pfizer Inc. Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
US5147873A (en) * 1988-08-23 1992-09-15 Pfizer Inc. Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
US4895943A (en) * 1988-10-25 1990-01-23 Pfizer Inc. Preparation of 1,4-diazabicyclo(3.2.2)nonane
US5036153A (en) * 1989-05-11 1991-07-30 Braish Tamim F Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates
US5214051A (en) * 1989-08-01 1993-05-25 Pfizer Inc. Thiazolyl and oxazolyl[5,4-c]piperidyl-substituted quinolone-carboxylic acid and related analogs thereof having antibacterial properties are disclosed
US5013839A (en) * 1989-09-25 1991-05-07 Pfizer Inc. Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1) heptanes
US5157125A (en) * 1989-09-25 1992-10-20 Pfizer Inc. Optically active 2-alkyl-2,5-diazabicyclo[2.2.1]heptanes
US5095121A (en) * 1989-09-25 1992-03-10 Pfizer Inc Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1)heptanes
US5385913A (en) * 1989-10-06 1995-01-31 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
WO1991004972A1 (en) * 1989-10-06 1991-04-18 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
US4992449A (en) * 1990-02-01 1991-02-12 American Cyanamid Company 7-(substituted)cycloalkylamino-1-(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
US5580872A (en) * 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
ATE115581T1 (de) * 1991-03-01 1994-12-15 Pfizer 1-azabicyclo(3.2.2>nonan-3-aminderivate.
US5235054A (en) * 1992-07-15 1993-08-10 Pfizer Inc. 3-carboxaldehyde substituted quinolines and naphthyridines
GB2291421A (en) * 1994-07-16 1996-01-24 Pfizer A process for preparing a quinoline carboxylic acid
ES2092963B1 (es) * 1995-04-12 1997-12-16 Sint Quimica Sa Procedimiento para la preparacion del acido 1-ciclopropil-6-fluoro-1, 4-dihidro-7-(1s,4s)-5-metil-2,5-diazabiciclo(2.2.1) hept-2-il)-4-oxo-3-quinolincarboxilico y sus sales.
US5929086A (en) * 1996-05-10 1999-07-27 Pharmacia & Upjohn Company Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases
US6056436A (en) * 1997-02-20 2000-05-02 University Of Maryland Simultaneous measurement of temperature and strain using optical sensors
US6114531A (en) * 1998-07-28 2000-09-05 Pfizer Inc. Process for preparing quinolone and naphthyridone carboxylic acids
DE60008866T2 (de) 1999-05-04 2005-01-27 Neurosearch A/S Heteroaryl diazabicycloalkene, deren herstellung und verwendung
FR2809730B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo[3.2.2] nonanebenzoxazole, -benzothiazole et -benzimidazole, leur preparation et leur application therapeutique
FR2809732B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
FR2809731B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique
JP4294958B2 (ja) * 2001-03-02 2009-07-15 ニューロサーチ、アクティーゼルスカブ 新規２，５−ジアザビシクロ［２．２．１］ヘプタン誘導体
JP2006504690A (ja) * 2002-09-10 2006-02-09 ファイザー・プロダクツ・インク Ｃｎｓ及びその他の障害の治療に有用なジアザ二環式化合物
HRP20050266A2 (en) * 2002-09-25 2005-10-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and uses thereof
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
JP4824578B2 (ja) * 2003-12-22 2011-11-30 メモリー・ファーマシューティカルズ・コーポレイション インドール類、１，２−ベンズイソオキサゾール類、および１，２−ベンゾイソチアゾール類、ならびにそれらの製造と使用
WO2005092890A2 (en) * 2004-03-25 2005-10-06 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
CA2567977A1 (en) * 2004-04-22 2006-01-05 Memory Pharmaceutical Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
US7632831B2 (en) * 2004-05-07 2009-12-15 Memory Pharmaceuticals Corporation 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
CA2591817A1 (en) 2004-12-22 2006-06-29 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
CA2641678A1 (en) 2006-02-10 2007-08-16 Neurosearch A/S 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7687517B2 (en) 2006-02-10 2010-03-30 Neurosearch A/S 3,9-Diazabicyclo [3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2007090888A1 (en) 2006-02-10 2007-08-16 Neurosearch A/S 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
DE102007026550A1 (de) 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
DE102007055341A1 (de) 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
WO2009111680A1 (en) * 2008-03-07 2009-09-11 Smithline Beecham Corporation Trpv4 antagonists
WO2010104205A1 (en) * 2009-03-11 2010-09-16 Kyorin Pharmaceutical Co., Ltd. 7-cycloalkylaminoquinolones as gsk-3 inhibitors
RU2627420C2 (ru) 2010-10-12 2017-08-08 Байер Интеллектчуал Проперти Гмбх Мягкие жвачки, не содержащие крахмала
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MD4291C1 (ro) * 2013-12-27 2015-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Preparat medicamentos pentru tratamentul otitelor
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US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent

Also Published As

Publication number Publication date
EP0215650A2 (en) 1987-03-25
BG61091B2 (bg) 1996-10-31
ZW19386A1 (en) 1986-12-10
HUT43070A (en) 1987-09-28
EG18184A (en) 1992-12-30
DE3683711D1 (de) 1992-03-12
YU161786A (en) 1987-10-31
ES2001428A6 (es) 1988-05-16
AU576302B2 (en) 1988-08-18
CA1340734C (en) 1999-09-14
MW5886A1 (en) 1987-12-09
NO170335C (no) 1992-10-07
LU90356I2 (fr) 1999-04-26
GR862363B (en) 1987-01-19
CY1774A (en) 1995-10-20
SG28094G (en) 1994-10-28
US4861779A (en) 1989-08-29
IE862479L (en) 1987-03-18
PT83388A (en) 1986-10-01
DD259190A5 (de) 1988-08-17
JPS62103083A (ja) 1987-05-13
DK445886A (da) 1987-05-27
PL149987B1 (en) 1990-04-30
CZ667886A3 (en) 1993-02-17
KR870003106A (ko) 1987-04-15
FI863756L (fi) 1987-03-19
IL80033A0 (en) 1986-12-31
NO863718L (no) 1987-03-19
DK171276B1 (da) 1996-08-19
NO863718D0 (no) 1986-09-17
CN86106385A (zh) 1987-06-03
ATE72245T1 (de) 1992-02-15
PT83388B (pt) 1989-05-12
ZA867063B (en) 1988-04-27
HK132795A (en) 1995-09-01
HU200462B (en) 1990-06-28
IN166416B (en]) 1990-05-05
US5091383A (en) 1992-02-25
UA6340A1 (uk) 1994-12-29
IE58966B1 (en) 1993-12-01
IL80033A (en) 1992-05-25
FI87565C (fi) 1993-01-25
FI87565B (fi) 1992-10-15
PL261410A1 (en) 1987-11-16
PH24048A (en) 1990-03-05
ZM8586A1 (en) 1987-03-27
SU1482531A3 (ru) 1989-05-23
EP0215650A3 (en) 1987-12-02
EP0215650B1 (en) 1992-01-29
BG49275A3 (en) 1991-09-16
AU6276886A (en) 1987-03-19
NO170335B (no) 1992-06-29
MA20770A1 (fr) 1987-04-01
OA08410A (fr) 1988-06-30
FI863756A0 (fi) 1986-09-17
MX173358B (es) 1994-02-23
SK278605B6 (en) 1997-11-05
NZ217614A (en) 1989-11-28
YU45024B (en) 1991-06-30
PH25338A (en) 1991-04-30
CZ277825B6 (en) 1993-06-16
CN1014789B (zh) 1991-11-20
SK667886A3 (en) 1997-11-05
KR870000961B1 (ko) 1987-05-14
MX3751A (es) 1993-09-01
DE19675019I2 (de) 2004-01-29
DK445886D0 (da) 1986-09-17
MY102518A (en) 1992-07-31
US4775668A (en) 1988-10-04

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